Discover a novel hybrid LC-MS approach for intact ADC quantification and overcome key bioanalytical challenges in ADC development
Dr. Issa Jyamubandi, Technical Expert at Intertek, presents "Acid Over Enzymes: Rethinking Intact ADC Quantification via Hybrid LC-MS."
This presentation explores the bioanalytical challenges associated with developing pharmacokinetic methods to support antibody-drug conjugate (ADC) therapeutics. Through a case study, Dr. Jyamubandi demonstrates a novel, versatile and cost-effective hybrid LC-MS approach for intact ADC quantification that uses acid hydrolysis in place of traditional enzymatic digestion.
The session examines the evolving bioanalytical landscape for ADCs, including method development and validation considerations, as well as the challenges associated with achieving accurate and reliable quantification throughout the drug development lifecycle.
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